Abstract |
Femoral and lumbar bone mineral densities (BMDs) were measured in 159 adults enrolled in the Leucémies de l'Enfant et de l'Adolescent program, a French prospective multicentric cohort of childhood leukemia survivors. BMDs were expressed as Z-scores, and multivariate linear regression analyses were used to construct association models with potential risk factors. Mean age at evaluation and follow-up was 23 and 14.7 years, respectively. In the whole cohort, mean femoral Z-score was -0.19 ± 0.08. Two factors were associated with lower femoral BMD transplantation (-0.49 ± 0.15 vs -0.04 ± 0.10 in the chemotherapy group; P = .006) and female sex (-0.34 ± 0.10 vs -0.03 ± 0.13; P = .03). Among patients who received a transplant, the only significant risk factor was hypogonadism (-0.88 ± 0.16 vs -0.10 ± 0.23; P = .04). A slight reduction in lumbar BMD (mean Z-score, -0.37 ± 0.08) was detected in the whole cohort without difference between the transplantation and chemotherapy groups. Among patients who received a transplant, younger age at transplantation was correlated with a low lumbar BMD (P = .03). We conclude that adults who had received only chemotherapy for childhood leukemia have a slight reduction in their lumbar BMD and a normal femoral BMD. Patients who received a transplant with gonadal deficiency have a reduced femoral BMD which might increase the fracture risk later in life.
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Authors | Marion Le Meignen, Pascal Auquier, Vincent Barlogis, Nicolas Sirvent, Audrey Contet, Marie-Claude Simeoni, Claire Galambrun, Marilyne Poirée, Pascal Chastagner, Barbara Play, Virginie Villes, Julie Berbis, Hervé Chambost, Pierre Bordigoni, Gérard Michel |
Journal | Blood
(Blood)
Vol. 118
Issue 6
Pg. 1481-9
(Aug 11 2011)
ISSN: 1528-0020 [Electronic] United States |
PMID | 21596857
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Absorptiometry, Photon
- Acute Disease
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bone Density
- Child
- Dexamethasone
(administration & dosage, adverse effects)
- Female
- Follow-Up Studies
- Hematopoietic Stem Cell Transplantation
- Humans
- Leukemia, Myeloid
(metabolism, therapy)
- Linear Models
- Male
- Multivariate Analysis
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(metabolism, therapy)
- Prednisone
(administration & dosage, adverse effects)
- Prospective Studies
- Survivors
- Young Adult
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