[The cyclin A, B1, D1 and E expression in advanced non-small cell lung cancer--stages IIIB-IV (preliminary report)].

Abstract

UNLABELLED:

Lung cancer is the leading cause of cancer death in the majority of developed countries. Uncontrolled cell proliferation is the hallmark of malignant tumours. Cyclins play an important role in cell cycle regulation. The aim of this study was to evaluate the expression of cyclins A, B1, D1 and E in advanced non-small cell lung cancer (stages IIIB-IV) with its prognostic significance.

MATERIAL AND METHOD:

An immunohistochemical assessment of cyclins A, B1, D1 and E expression was performed in the paraffin-embedded tumor tissues of 19 patients (9 men and 10 women). The mean was age 59 +/- 6.64 years. 9 patients were in IIIB and 10 in IV. The 2-years survival rate was evaluated.

RESULTS:

We showed positive cyclin A expression in 13 tumor tissue specimens (68%), cyclin B1 in 3 (16%), cyclin D1 in 9 (47%) and cyclin E in 7 (37%). We analyzed the prognostic value of examinated cyclins in all NSCLC patients and separately in patients with squamous cell lung cancer and adenocarcinoma and in patients in stage IIIB and IV, but we have no found any correlations. We did not find also any differences in examinated cyclins expression depending on stages nor different histopathological types.

CONCLUSION:

We did not observe prognostic value of cyclins A, B1, D1 or E expression in advanced non-small cell lung cancer.

• Authors: Monika Kosacka, Paweł Piesiak, Irena Porebska, Anna Korzeniewska, Renata Jankowska
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 30 Issue 178 Pg. 253-8 (Apr 2011) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Ekspresja cyklin A, B1, D1 i E w zaawansowanym niedrobnokomórkowym raku płuca--stadia IIIB-IV (doniesienie wstepne).
• PMID: 21595169 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• Cyclin A
• Cyclin B1
• Cyclin E
• Cyclins
• Cyclin D1

Topics

• Adenocarcinoma (metabolism, pathology)
• Biomarkers, Tumor (metabolism)
• Carcinoma, Non-Small-Cell Lung (metabolism, mortality, pathology)
• Carcinoma, Squamous Cell (metabolism, pathology)
• Cyclin A (metabolism)
• Cyclin B1 (metabolism)
• Cyclin D1 (metabolism)
• Cyclin E (metabolism)
• Cyclins (metabolism)
• Female
• Humans
• Immunohistochemistry
• Lung Neoplasms (metabolism, mortality, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Survival Rate