Abstract |
The peripheral levels of 17-hydroxypregnenolone (17delta5P), progesterone (P), 17-hydroxyprogesterone (17P), testosterone (T), 5alpha-dihydrotestosterone (DHT), androstenedione (A), androst-5-ene-3beta,17beta-diol (delts5diol), dehydroepiandrosterone ( DHEA), dehydroepiandrosterone sulfate ( DHEA-S), estradiol-17beta (E2), and cortisol (F) were measured in peripheral and right adrenal venous blood of an amenorrheic patient with a right virilizing adrenal adenoma. Urinary 17-ketosteroids were markedly elevated and were not suppressed on a low dose of dexamethasone (Dex) for 7 days. Peripheral T level was 1.2 ng/ml and DHEA-S was 13,500 ng/ml. Calculations of the ratios of adrenal venous gradients for delta5 and delta4 steroids suggest that the predominant pathway of steroid secretion used by the tumor was as follows: pregnenolone (delta5P) leads to 17delta5P leads to DHEA leads to A leads to T. Following removal of the adenoma, T returned to normal levels but DHEA-S was still above normal at 4100 ng/ml. The patient became eumenorrheic with marked improvement at her hirsutism and virilization.
|
Authors | A B Granoff, G E Abraham |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 53
Issue 1
Pg. 111-5
(Jan 1979)
ISSN: 0029-7844 [Print] United States |
PMID | 215946
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- 17-Hydroxycorticosteroids
- Androstanes
- Androstenediols
- Gonadal Steroid Hormones
- Hydroxyprogesterones
- Dihydrotestosterone
- 17-alpha-Hydroxypregnenolone
- Testosterone
- Androstenedione
- Dehydroepiandrosterone
- Estradiol
- Hydrocortisone
|
Topics |
- 17-Hydroxycorticosteroids
(blood)
- 17-alpha-Hydroxypregnenolone
(blood)
- Adenoma
(blood, metabolism)
- Adolescent
- Adrenal Gland Neoplasms
(blood, metabolism)
- Adrenal Glands
(blood supply)
- Androstanes
(blood)
- Androstenediols
(blood)
- Androstenedione
(blood)
- Dehydroepiandrosterone
(blood)
- Dihydrotestosterone
(blood)
- Estradiol
(blood)
- Female
- Gonadal Steroid Hormones
(blood)
- Humans
- Hydrocortisone
(blood)
- Hydroxyprogesterones
(blood)
- Testosterone
(blood)
- Veins
|