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A comparison of Jurkat cell-reactive anti-T lymphocyte globulin and fetal anti-thymocyte globulin preparations in the treatment of aplastic anemia.

AbstractOBJECTIVE:
The aim of this study was to investigate the success rate and effects on survival of different anti-thymocyte globulin (ATG) preparations in patients diagnosed with aplastic anemia.
SUBJECTS AND METHODS:
Of the total 24 patients included in the study, 12 were male and 12 female with a median age of 44 years (range 16-72). Nine patients received Lymphoglobulin®, 7 Thymoglobulin® and ATG-Fresenius® (ATG-F). There was no significant difference between the three treatment groups in terms of severity of aplastic anemia.
RESULTS:
The estimated 6-month survival rates for ATG-F, Lymphoglobulin and Thymoglobulin groups were 42.9, 77.8 and 71.4%, respectively. The difference in overall survival rates between groups was not significant, most likely due to the low number of patients. The most striking result was that none of the patients in the ATG-F preparation group showed any response to treatment. The ATG-F group was found to have a significantly inferior response rate (p = 0.07).
CONCLUSION:
Our data showed that none of the patients responded to ATG-F treatment. Hence, despite the small number of the patients, we recommend that ATG-F should not be used for treatment of severe aplastic anemia.
AuthorsSongul Serefhanoglu, Yahya Buyukasik, Tugrul Purnak, Hakan Goker, Nılgun Sayinalp, Ibrahim C Haznedaroglu, Osman I Ozcebe
JournalMedical principles and practice : international journal of the Kuwait University, Health Science Centre (Med Princ Pract) Vol. 20 Issue 4 Pg. 341-4 ( 2011) ISSN: 1423-0151 [Electronic] Switzerland
PMID21576994 (Publication Type: Comparative Study, Journal Article)
CopyrightCopyright © 2011 S. Karger AG, Basel.
Chemical References
  • Antilymphocyte Serum
  • Immunoglobulin G
Topics
  • Adolescent
  • Adult
  • Aged
  • Anemia, Aplastic (therapy)
  • Antilymphocyte Serum (analysis, immunology, therapeutic use)
  • Female
  • Humans
  • Immunoglobulin G (analysis, immunology)
  • Jurkat Cells (immunology)
  • Male
  • Middle Aged
  • Retrospective Studies
  • Statistics as Topic
  • T-Lymphocytes (immunology)
  • Turkey
  • Young Adult

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