[Association of hemostatic disorders in diabetic patients with methylenetetrahydrofolate reductase (C677T) and coagulation factors II (G20210A) and V (G1691A) gene polymorphism].

Abstract

The purpose of the investigation was to study an association of hemostatic disorders in diabetic patients with methylenetetrahydrofolate reductase (MTHFR) (C677T) and coagulation factors II (G20210A) and V (G1691A) gene polymorphism. The investigators examined 90 patients with diabetic nephropathy complicating types 1 and 2 diabetes in 54 and 36 cases, respectively. A control group comprised 100 healthy individuals. A polymerase chain reaction was used to diagnose single-nucleotide substitution of C6777T in the MTHFR gene, a point mutation in the coagulation factor V (FV) gene, and a factor II (FII) G20210A gene mutation in the coagulation factor II (FII) gene. The parameters of platelet and coagulation hemostasis were analyzed. Gene mutations (C677T in the MTHFR gene, G1691A in the FV gene and G20210A in FII gene) are encountered in diabetic patients more frequently than those in healthy individuals. The mutations are associated with increased blood coagulation potential and platelet hyperactivation.

• Authors: O F Sibireva
• Journal: Klinicheskaia laboratornaia diagnostika (Klin Lab Diagn) Issue 3 Pg. 36-9 (Mar 2011) ISSN: 0869-2084 [Print] Russia (Federation)
• PMID: 21574459 (Publication Type: English Abstract, Journal Article)

Chemical References

• Factor V
• Prothrombin
• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Adult
• Aged
• Diabetes Mellitus, Type 1 (complications, genetics)
• Diabetes Mellitus, Type 2 (complications, genetics)
• Factor V (genetics)
• Female
• Gene Frequency (genetics)
• Genetic Predisposition to Disease
• Hemostatic Disorders (etiology, genetics)
• Humans
• Male
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• Middle Aged
• Point Mutation (genetics)
• Polymorphism, Single Nucleotide
• Prothrombin (genetics)