Stereotactic radiosurgery and hypofractionated stereotactic radiotherapy: normal tissue dose constraints of the central nervous system.

Abstract

Single-fraction stereotactic radiosurgery (SRS) and hypofractionated stereotactic radiotherapy (SRT) are radiation planning and delivery techniques used for the treatment of intracranial and spine/spinal cord tumors and targets. For cranial SRS and SRT, critical normal tissues/structures include the brainstem, cranial nerves, cochlea and normal brain parenchyma. For spine SRS/SRT, critical normal tissues/structures include the spinal cord, cauda equina as well as neighboring organs. This paper reviews clinical studies investigating central nervous system dose tolerances after cranial or spinal SRS/SRT. The impact of dose, volume, fractionation, and other relevant clinic-pathologic variables are discussed, as are limitations of the published data.

• Authors: Michael T Milano, Kenneth Y Usuki, Kevin A Walter, Douglas Clark, Michael C Schell
• Journal: Cancer treatment reviews (Cancer Treat Rev) Vol. 37 Issue 7 Pg. 567-78 (Nov 2011) ISSN: 1532-1967 [Electronic] Netherlands
• PMID: 21571440 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Topics

• Brain Neoplasms (surgery)
• Central Nervous System (radiation effects)
• Dose Fractionation, Radiation
• Humans
• Radiosurgery