[Rifaximin in combined treatment of the Helicobacter pylori infection in childhood].

Abstract

AIM:

To provide a pilot study of empiric rifaximin, bismuth subcitrate, furazolidone/nifuratel triple therapy for H. pylori gastritis in childhood.

MATERIALS AND METHODS:

Forty one pediatric outpatients (27 females, mean age 14.5 +/- 1.4 ys) with H. pylori-associated chronic gastritis who underwent endoscopy for dyspeptic symptoms received the combination of bismuth subcitrate (8/mg/kg/day, q. d. s.) for 14 days, rifaximin (800 mg/day) for 10 days and furazolidone (10 mg/kg/day, q. d. s.) or nifuratel (15 mg/kg/two times daily) for 10 days. H. pylori status was determined before the treatment by modified Giemsa staining/urease test and after the treatment (in 4-6 weeks) by ammonia breath test.

RESULTS:

H. pylori was eradicated in 35 children (85.4%; 95% CI: 75.4-96.4 ITT and PP tests). There were no serious adverse reactions and were no withdrawals due to any side effects.

CONCLUSION:

The combination of rifaximin, bismuth subcitrate and furazolidone/nifuratel was an effective and tolerable regimen for initial H. pylori eradication.

• Authors: A A Nizhevich, P L Shcherbakov, É N Akhmadeeva, R Sh Khasanov
• Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology (Eksp Klin Gastroenterol) Issue 1 Pg. 85-7 ( 2011) ISSN: 1682-8658 [Print] Russia (Federation)
• PMID: 21560396 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Organometallic Compounds
• Rifamycins
• Furazolidone
• bismuth tripotassium dicitrate
• Rifaximin

Topics

• Adolescent
• Anti-Infective Agents (administration & dosage, adverse effects)
• Child
• Drug Therapy, Combination (methods)
• Female
• Furazolidone (administration & dosage, adverse effects)
• Helicobacter Infections (drug therapy)
• Helicobacter pylori
• Humans
• Male
• Organometallic Compounds (administration & dosage, adverse effects)
• Rifamycins (administration & dosage, adverse effects)
• Rifaximin