Abstract |
1. Benzodiazepines are involved in the control of proliferation and differentiation of normal and malignant cells in vitro. This regulatory ability is probably mediated via peripheral benzodiazepine-binding sites. 2. In the present study we compared the binding characteristics of peripheral benzodiazepine-binding sites in human epithelial ovarian carcinoma with those in benign ovarian tumours and normal ovaries. 3. The affinity and density of peripheral benzodiazepine-binding sites in homogenate preparations of ovarian carcinoma as compared with benign ovarian tumours and with normal tissues (used as controls) were determined using a ligand specific for peripheral benzodiazepine-binding sites, [3H] PK 11195, an isoquinoline carboxamide derivative. 4. We observed a robust (three- to five-fold) increase in the neoplasm compared with benign ovarian tumours and normal tissues, without a concomitant change in affinity values. 5. This finding may reflect a change in the metabolic rates of ovarian cancer which is expressed as the alteration in the density of peripheral benzodiazepine-binding sites.
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Authors | Y Katz, G Ben-Baruch, Y Kloog, J Menczer, M Gavish |
Journal | Clinical science (London, England : 1979)
(Clin Sci (Lond))
Vol. 78
Issue 2
Pg. 155-8
(Feb 1990)
ISSN: 0143-5221 [Print] England |
PMID | 2155741
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoquinolines
- Receptors, GABA-A
- Benzodiazepines
- PK 11195
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Topics |
- Adenocarcinoma, Papillary
(metabolism)
- Adult
- Aged
- Benzodiazepines
(metabolism)
- Binding Sites
- Female
- Humans
- Isoquinolines
(metabolism)
- Middle Aged
- Ovarian Diseases
(metabolism)
- Ovarian Neoplasms
(metabolism)
- Ovary
(metabolism)
- Receptors, GABA-A
(metabolism)
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