Coverage of gingival recession defects using guided tissue regeneration with and without adjunctive enamel matrix derivative in a dog model.

Abstract

The aim of this study was to clarify the adjunctive effect of enamel matrix derivative (EMD) on expanded polytetrafluoroethylene membrane guided tissue regeneration (GTR)-based root coverage by creating gingival recessions in beagle dogs. Recessions were treated with GTR + EMD, GTR alone, or neither GTR nor EMD (control). The control group was characterized by long junctional epithelium and little bone formation. The GTR + EMD group showed a statistically significant increase (P < .01) in new bone and cementum formation compared with the GTR group. The results of the present investigation suggest that the adjunctive use of EMD with GTR promotes formation of new bone and cementum without root resorption in recession-type defects in dogs.

• Authors: Takahisa Fujita, Shigeki Yamamoto, Mikio Ota, Yoshihiro Shibukawa, Satoru Yamada
• Journal: The International journal of periodontics & restorative dentistry (Int J Periodontics Restorative Dent) Vol. 31 Issue 3 Pg. 247-53 (Jun 2011) ISSN: 0198-7569 [Print] United States
• PMID: 21556381 (Publication Type: Journal Article)

Chemical References

• Bone Substitutes
• Dental Enamel Proteins
• Membranes, Artificial
• enamel matrix proteins
• Polytetrafluoroethylene

Topics

• Animals
• Bone Regeneration (drug effects)
• Bone Substitutes (pharmacology)
• Cementogenesis (drug effects)
• Dental Enamel Proteins (pharmacology)
• Dogs
• Gingival Recession (surgery)
• Guided Tissue Regeneration, Periodontal (methods)
• Implants, Experimental
• Membranes, Artificial
• Polytetrafluoroethylene