Abstract |
The effects of cinnamaldehyde (CINN) on in vitro parameters of immunity and in vivo protection against avian coccidiosis were evaluated. In vitro stimulation of chicken spleen lymphocytes with CINN (25-400 ng/ml) induced greater cell proliferation compared with the medium control (P < 0·001). CINN activated cultured macrophages to produce higher levels of NO at 1·2-5·0 μg/ml (P < 0·001), inhibited the growth of chicken tumour cells at 0·6-2·5 μg/ml (P < 0·001) and reduced the viability of Eimeria tenella parasites at 10 and 100 μg/ml (P < 0·05 and P < 0·001, respectively), compared with media controls. In chickens fed a diet supplemented with CINN at 14·4 mg/kg, the levels of IL-1β, IL-6, IL-15 and interferon-γ transcripts in intestinal lymphocytes were 2- to 47-fold higher (P < 0·001) compared with chickens given a non-supplemented diet. To determine the effect of CINN diets on avian coccidiosis, chickens were fed diets supplemented with CINN at 14·4 mg/kg (E. maxima or E. tenella) or 125 mg/kg (E. acervulina) from hatch for 24 d, and orally infected with 2·0 × 10(4) sporulated oocysts at age 14 d. CINN-fed chickens showed 16·5 and 41·6 % increased body-weight gains between 0-9 d post- infection (DPI) with E. acervulina or E. maxima, reduced E. acervulina oocyst shedding between 5-9 DPI and increased E. tenella-stimulated parasite antibody responses at 9 DPI compared with controls.
|
Authors | Sung Hyen Lee, Hyun S Lillehoj, Seung I Jang, Kyung Woo Lee, Myeong Seon Park, David Bravo, Erik P Lillehoj |
Journal | The British journal of nutrition
(Br J Nutr)
Vol. 106
Issue 6
Pg. 862-9
(Sep 2011)
ISSN: 1475-2662 [Electronic] England |
PMID | 21554819
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Antimutagenic Agents
- Interleukin-15
- Interleukin-1beta
- Interleukin-6
- Nitric Oxide
- Acrolein
- Interferon-gamma
- cinnamaldehyde
|
Topics |
- Acrolein
(analogs & derivatives, pharmacology)
- Animals
- Antimutagenic Agents
(pharmacology)
- Cell Line, Tumor
- Cell Proliferation
- Chickens
- Coccidiosis
(immunology, metabolism)
- In Vitro Techniques
- Interferon-gamma
(metabolism)
- Interleukin-15
(metabolism)
- Interleukin-1beta
(metabolism)
- Interleukin-6
(metabolism)
- Lymphocytes
(cytology, immunology)
- Macrophages
(metabolism)
- Nitric Oxide
(metabolism)
- Oocysts
(metabolism)
- Spleen
(cytology, immunology)
|