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Botulinum toxin type A on oral health in treating sialorrhea in children with cerebral palsy: a randomized, double-blind, placebo-controlled study.

Abstract
Intrasalivary gland injection of botulinum toxin type A is known to treat sialorrhea effectively in children with cerebral palsy. However, oral health may be compromised with escalating dose. In this randomized, double-blind, and placebo-controlled pilot trial, the authors aim to determine the therapeutic effect of low-dose, ultrasonography-controlled botulinum toxin type A injection to bilateral parotid and submandibular glands on oral health in the management of sialorrhea. Twenty children diagnosed with cerebral palsy were randomly assigned to 2 groups. The treatment group received botulinum toxin type A injections, whereas the control received normal saline in the same locations. The authors evaluated subjective drooling scales, salivary flow rate, and oral health (salivary compositions and cariogenic bacterial counts). A significant decrease was found in salivary flow rate at the 1- and 3-month follow-up in the botulinum toxin-treated group. The authors suggest that current protocol can effectively manage sialorrhea while maintaining oral health.
AuthorsKatie Pei-Hsuan Wu, Jyh-Yuh Ke, Chung-Yao Chen, Chia-Ling Chen, Ming-Yen Chou, Yu-Cheng Pei
JournalJournal of child neurology (J Child Neurol) Vol. 26 Issue 7 Pg. 838-43 (Jul 2011) ISSN: 1708-8283 [Electronic] United States
PMID21551374 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Neurotoxins
  • Placebos
  • Botulinum Toxins, Type A
Topics
  • Adolescent
  • Botulinum Toxins, Type A (administration & dosage, adverse effects)
  • Cerebral Palsy (complications)
  • Child
  • Child, Preschool
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Neurotoxins (administration & dosage, adverse effects)
  • Pilot Projects
  • Placebos
  • Saliva (chemistry, drug effects, metabolism)
  • Sialorrhea (drug therapy, etiology, physiopathology)

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