Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: We hypothesize that there may be a common pathogenic mechanism between LGL leukemia and typical Felty's syndrome. Phenotypic and functional data have strongly suggested that CD3 LGL leukemia is antigen-activated. Aberrations in the T-cell repertoire with the emergence of oligoclonal/clonal lymphoid populations have been found to play a pivotal role in pathogenesis of RA. The biologic properties of the pivotal T cell involved in RA pathogenesis are remarkably similar to those in leukemic LGL. SUMMARY:
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Authors | Xin Liu, Thomas P Loughran Jr |
Journal | Current opinion in hematology
(Curr Opin Hematol)
Vol. 18
Issue 4
Pg. 254-9
(Jul 2011)
ISSN: 1531-7048 [Electronic] United States |
PMID | 21546829
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
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Topics |
- Arthritis, Rheumatoid
(immunology, pathology)
- Felty Syndrome
(immunology, pathology)
- HLA-DR4 Antigen
(immunology)
- Histocompatibility Testing
- Humans
- Leukemia, Large Granular Lymphocytic
(immunology, pathology)
- Neutropenia
(immunology, pathology)
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