AA amyloidosis associated with hepatitis B.

Abstract

We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Furthermore, mass spectrometry also detected a variant of SAA protein (SAA W71R).

• Authors: Abhijeet Saha, Jason D Theis, Julie A Vrana, Nand K Dubey, Vineeta V Batra, Sanjeev Sethi
• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 26 Issue 7 Pg. 2407-12 (Jul 2011) ISSN: 1460-2385 [Electronic] England
• PMID: 21543651 (Publication Type: Case Reports, Journal Article)

Chemical References

• Serum Amyloid A Protein

Topics

• Amino Acid Sequence
• Amyloidosis (complications, metabolism)
• Child
• Chromatography, Liquid
• Hepatitis B (complications, metabolism)
• Hepatitis B virus (pathogenicity)
• Humans
• Kidney Glomerulus (physiopathology)
• Lasers
• Male
• Microdissection
• Molecular Sequence Data
• Nephrotic Syndrome (etiology, metabolism)
• Prognosis
• Serum Amyloid A Protein (metabolism)
• Tandem Mass Spectrometry