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A review of systemic opioids commonly used for labor pain relief.

Abstract
Parenteral opioids for pain relief during labor have been the subject of research for many decades. Commonly used systemic opioids provide limited pain relief during labor yet are used extensively for managing labor pain. These opioids share similar pharmacologic profiles but differ in potency, pharmacokinetics, and side effects. This article reviews the pharmacokinetics, pharmacodynamics, and clinical research related to the commonly used systemic labor pain analgesics morphine, meperidine, fentanyl, remifentanil, butorphanol, and nalbuphine.
AuthorsDeborah Anderson
JournalJournal of midwifery & women's health (J Midwifery Womens Health) 2011 May-Jun Vol. 56 Issue 3 Pg. 222-39 ISSN: 1542-2011 [Electronic] United States
PMID21535371 (Publication Type: Journal Article, Review)
Copyright© 2011 by the American College of Nurse-Midwives.
Chemical References
  • Analgesics, Opioid
  • Piperidines
  • Morphine
  • Meperidine
  • Nalbuphine
  • Remifentanil
  • Butorphanol
  • Fentanyl
Topics
  • Analgesia, Obstetrical (methods)
  • Analgesics, Opioid (pharmacology)
  • Breast Feeding
  • Butorphanol (pharmacology)
  • Female
  • Fentanyl (pharmacology)
  • Humans
  • Labor Pain (drug therapy)
  • Meperidine (pharmacology)
  • Morphine (pharmacology)
  • Nalbuphine (pharmacology)
  • Pharmacogenetics
  • Piperidines (pharmacology)
  • Pregnancy
  • Remifentanil

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