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Treatment of giant Bowen's disease with sequential use of photodynamic therapy and imiquimod cream.

Abstract
We present a 79-year-old man with a 2-year history of Bowen's disease. The 10 × 10 plaque was located on the right frontotemporal area. The patient was treated with two photodynamic therapy (PDT) sessions, performed 1 week apart, followed by five times per week application of imiquimod 5% cream for 6 consecutive weeks. Complete clinical and histological response was achieved 3 months after treatment was completed. The patient remains recurrence free 12 months after treatment. Cosmetic outcome was evaluated as fair because of residual erythema. Long-term follow-up is mandatory for assessment of recurrences. Further studies are needed in order to confirm the improved outcome using the combination of PDT and imiquimod cream.
AuthorsEleni Sotiriou, Aimilios Lallas, Zoi Apalla, Demetris Ioannides
JournalPhotodermatology, photoimmunology & photomedicine (Photodermatol Photoimmunol Photomed) Vol. 27 Issue 3 Pg. 164-6 (Jun 2011) ISSN: 1600-0781 [Electronic] England
PMID21535173 (Publication Type: Case Reports, Journal Article)
Copyright© 2011 John Wiley & Sons A/S.
Chemical References
  • Aminoquinolines
  • Antineoplastic Agents
  • Imiquimod
Topics
  • Administration, Topical
  • Aged
  • Aminoquinolines (administration & dosage)
  • Antineoplastic Agents (administration & dosage)
  • Bowen's Disease (drug therapy, pathology)
  • Head and Neck Neoplasms (drug therapy, pathology)
  • Humans
  • Imiquimod
  • Male
  • Photochemotherapy
  • Remission Induction
  • Skin Neoplasms (drug therapy, pathology)

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