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Peptide vaccination induces profound changes in the immune system in patients with B-cell chronic lymphocytic leukemia.

Abstract
Although the immune status of chronic lymphocytic leukemia (CLL) patients is mostly characterized by immunosuppression, there is an accumulation of in vivo (graft-versus-leukemia effect) and in vitro (spontaneous remissions after infections) data that indicates that CLL might be effectively targeted by T-cell based immunotherapy. Recently, we characterized receptor for hyaluronic acid mediated motility (RHAMM) as a preferential target for immunotherapy of CLL. We also completed a RHAMM-derived peptide vaccination phase I/II clinical trial in CLL. Here, we present a detailed immunological analysis of six CLL patients vaccinated with HLA-A2 restricted RHAMM-derived epitope R3 (ILSLELMKL). Beside effective induction of R3-specific cytotoxic T-cells, peptide vaccination caused profound changes in different T-cell subsets as well as cytokines. We present longitudinal analyses of Th17, CD8(+)CD103(+), CD8(+)CD137(+) and IL-17 producing CD8(+) T cells (CD8(+)IL- -17(+)) as well as important cytokines involved in regulation of immune response such as TGF-β, IL-10, IL-2 and TNF throughout the peptide vaccination period.
AuthorsKrzysztof Giannopoulos, Paulina Własiuk, Anna Dmoszyńska, Jacek Roliński, Michael Schmitt
JournalFolia histochemica et cytobiologica (Folia Histochem Cytobiol) Vol. 49 Issue 1 Pg. 161-7 ( 2011) ISSN: 1897-5631 [Electronic] Poland
PMID21526504 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Cancer Vaccines
  • Cytokines
  • Peptide Fragments
Topics
  • Adult
  • Aged
  • Cancer Vaccines (adverse effects, immunology)
  • Cytokines (blood, immunology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell (diagnosis, immunology, therapy)
  • Male
  • Middle Aged
  • Peptide Fragments (adverse effects, immunology)
  • T-Lymphocyte Subsets (drug effects, immunology, pathology)
  • Vaccination

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