Candidemia in children after complex congenital heart defects surgery treated with caspofungin--our own experience and a review of literature.

Abstract

BACKGROUND:

Invasive fungal infections due to Candida species constitute an increasing clinical problem. There are no guidelines for the management of candidemia in children undergoing surgical procedures for congenital heart defects (CHD). The aim of the study was to draw attention to the problem of candidemia in children who are operated on due to congenital heart defects.

MATERIAL/METHODS:

We retrospectively analyzed medical documentation of 307 children with congenital heart defects treated in 1 clinical centre in Poland, from whom we selected those diagnosed with candidemia during the postoperative period. Next, we analyzed in detail the clinical course of invasive candidiasis in each individual and we performed an analysis of risk factors that lead to candidemia.

RESULTS:

In the analyzed period, among 307 children who underwent surgical procedures, we observed 2 cases of candidemia (0.65%) which were effectively cured with caspofungin. No adverse effects were observed after treatment with the drug.

CONCLUSIONS:

Candidemia in children who undergo surgical treatment of congenital heart defects is an important factor that can influence final clinical results. Caspofungin may be an effective therapeutic option when treating candidemia in children after extensive cardiosurgical procedures.

• Authors: Radoslaw Jaworski, Ninela Irga, Ireneusz Haponiuk, Maciej Chojnicki, Elzbieta Arlukowicz, Mariusz Steffek, Mariusz Sroka, Katarzyna Gierat-Haponiuk, Jacek Juscinski, Lucyna Palkowska, Aneta Sendrowska, Wojciech Kosiak
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 17 Issue 5 Pg. PH35-9 (May 2011) ISSN: 1643-3750 [Electronic] United States
• PMID: 21525820 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antifungal Agents
• Echinocandins
• Lipopeptides
• C-Reactive Protein
• Caspofungin

Topics

• Antifungal Agents (therapeutic use)
• C-Reactive Protein (metabolism)
• Candidemia (blood, drug therapy, etiology)
• Cardiac Surgical Procedures (adverse effects)
• Caspofungin
• Child
• Echinocandins (therapeutic use)
• Female
• Heart Defects, Congenital (surgery)
• Humans
• Infant
• Leukocyte Count
• Lipopeptides