Abstract | BACKGROUND:
Non-alcoholic fatty liver disease ( NAFLD) has a high prevalence in obese children. Lifestyle intervention is the primary treatment for NAFLD. However, limited data are available regarding the efficacy of lifestyle interventions. OBJECTIVES: To prospectively determine the efficacy of a lifestyle intervention programme on NAFLD in severely obese children and identify the clinical parameters related to improvement in NAFLD. METHODS: RESULTS: 144 children were included with a mean age of 14.1 (±2.3) years, BMI z-score of 3.35 (±0.40) kg/m(2). Lifestyle intervention significantly reduced the prevalence of steatosis (31.2-11.9%, p<0.001) and the prevalence of elevated serum ALT (25.7-11.1%, p<0.001) and serum AST (13.3-4.3%, p<0.002). In multivariate regression analysis, improvement in the degree of steatosis and decrease in ALT and AST were all significantly related to improvement in insulin resistance. Improvement in insulin resistance only explained a small part of the observed changes in transaminases. CONCLUSIONS: A lifestyle intervention of 6 months is moderately effective in improving NAFLD in severely obese children. Improvement in insulin resistance is the clinical parameter most strongly associated with improvement in NAFLD. Other factors related to the successful treatment of NAFLD need to be identified so that these can be a focus for new lifestyle and drug interventions.
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Authors | Bart G P Koot, Olga H van der Baan-Slootweg, Christine L J Tamminga-Smeulders, Tammo H Pels Rijcken, Joke C Korevaar, Wim M van Aalderen, Peter L M Jansen, Marc A Benninga |
Journal | Archives of disease in childhood
(Arch Dis Child)
Vol. 96
Issue 7
Pg. 669-74
(Jul 2011)
ISSN: 1468-2044 [Electronic] England |
PMID | 21518734
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Anthropometry
(methods)
- Behavior Therapy
(methods)
- Child
- Combined Modality Therapy
(methods)
- Epidemiologic Methods
- Exercise Therapy
(methods)
- Fatty Liver
(diagnostic imaging, etiology, physiopathology, rehabilitation)
- Female
- Humans
- Insulin Resistance
(physiology)
- Life Style
- Male
- Non-alcoholic Fatty Liver Disease
- Obesity
(complications)
- Transaminases
(blood)
- Treatment Outcome
- Ultrasonography
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