Abstract | OBJECTIVE: DESIGN: Prospective clinical study. SETTING: University-affiliated teaching hospital. PARTICIPANTS: Ninety-one patients with acute dry traumatic tympanic membrane perforation inverted or everted edges were recruited. They were randomly allocated to three groups: spontaneous healing (n=31), gelfoam patching ( n=30) and edge-approximation plus gelfoam patching ( n=30). Otoscopy and tympanometry were performed before the treatment and at follow-up visits. MAIN OUTCOME MEASURES: Healing rate, healing time, ear infection rate and morphological changes during healing process. RESULTS: The overall healing rate was 85% in the spontaneous healing group, lower than that in the two gelfoam patching groups (97%), but the difference failed to reach a statistical significance (P>0.05). The average healing time was 30 ± 10.1 days in the spontaneous healing group, significantly longer (P<0.01) than that in the other two groups (16 ± 5.6 and 18 ± 4.7 days, respectively). Middle ear infection rate did not differ significantly (7%, 3% and 3%, respectively). Spontaneous healing resulted in formation of scabs at the perforation edges, which was effectively prevented by gelfoam patching. CONCLUSIONS:
Gelfoam patching may facilitate healing of traumatically perforated tympanic membrane. Approximation of folded perforation edges is not necessary in gelfoam patching.
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Authors | Z-C Lou, J-G He |
Journal | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
(Clin Otolaryngol)
Vol. 36
Issue 3
Pg. 221-6
(Jun 2011)
ISSN: 1749-4486 [Electronic] England |
PMID | 21518294
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 Blackwell Publishing Ltd. |
Chemical References |
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Topics |
- Adult
- Female
- Follow-Up Studies
- Gelatin Sponge, Absorbable
(therapeutic use)
- Head Injuries, Closed
(complications)
- Hemostatics
(therapeutic use)
- Humans
- Male
- Middle Aged
- Otoscopy
- Prospective Studies
- Treatment Outcome
- Tympanic Membrane
(injuries, pathology, surgery)
- Tympanic Membrane Perforation
(diagnosis, etiology, surgery)
- Tympanoplasty
(methods)
- Wound Healing
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