Abstract |
Gliomatosis cerebri (GC) constitutes a heterogeneous group of conditions involving diffuse neoplastic glial cell infiltration of the brain. Management is difficult and an obvious challenge is to identify prognostic factors. Alpha-internexin (INA) expression, which is closely related to the 1p19q codeletion, is a strong prognostic marker in oligodendroglial tumors. Similarly, the R132H isocitrate dehydrogenase 1 IDH1 mutation, which can now be detected by use of a specific antibody, predicts better outcome in gliomas. In a retrospective series of 40 GC treated with up-front chemotherapy, we analyzed IDH1(R132H) mutant protein and INA immunohistochemical expression and correlated it with outcome; 17/40 GC expressed IDH1(R132H) and 10/40 GC expressed INA. IDH1(R132H) staining was strongly related to progression-free survival (42.3 vs. 15.5 months for positive IDH1(R132H) vs. negative tumors; P < 0.0001) and overall survival (73.9 vs. 23.6 months; P < 0.0001). This effect was independent of grade, histologic subtype, and INA expression (P < 0.001). Combined expression of IDH1(R132H) and INA was strongly associated with response to chemotherapy (100% vs. 36%; P = 0.003). These data strongly suggest that INA and IDH1(R132H) mutant protein immunohistochemical analysis is of a great prognostic value in biopsied GC.
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Authors | Virginie Desestret, Pietro Ciccarino, François Ducray, Emmanuelle Crinière, Blandine Boisselier, Marianne Labussière, Marc Polivka, Ahmed Idbaih, Gentian Kaloshi, Andreas von Deimling, Khe Hoang-Xuan, Jean-Yves Delattre, Karima Mokhtari, Marc Sanson |
Journal | Journal of neuro-oncology
(J Neurooncol)
Vol. 105
Issue 2
Pg. 219-24
(Nov 2011)
ISSN: 1573-7373 [Electronic] United States |
PMID | 21516462
(Publication Type: Journal Article)
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Chemical References |
- Intermediate Filament Proteins
- Mutant Proteins
- alpha-internexin
- Isocitrate Dehydrogenase
- IDH1 protein, human
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Follow-Up Studies
- Humans
- Immunoenzyme Techniques
- Intermediate Filament Proteins
(metabolism)
- Isocitrate Dehydrogenase
(metabolism)
- Mutant Proteins
(metabolism)
- Neoplasms, Neuroepithelial
(drug therapy, metabolism, mortality)
- Polymorphism, Single Nucleotide
(genetics)
- Prognosis
- Retrospective Studies
- Survival Rate
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