Relationship between Helicobacter pylori infection estimated by 14C-urea breath test and gender, blood groups and Rhesus factor.

Abstract

The aim of this study was the detection of helicobacter pylori (HP) infection and estimation of this infection relationship with age, gender, blood groups and Rhesus factor, as well as the assessment of the accuracy of the method. A total of 227 patients with gastritis were examined. Blood ABO groups and Rh positivity were determined using standard tests. Infection by HP was proved by (14)C-urea breath test and gastric biopsy. Patients were aged 20-81 years (X=51.7 years) and the presence of HP was not related to the age (P>0.05). From the total number of patients, 25/69 males and 68/158 females were HP positive. There was no significant difference between genders and HP infection (P>0.05). From the 227 investigated patients, 69 (30%) belonged to blood group O, 96 (42%) to A, 40 (18%) to B and 22 (10%) to AB. HP was detected in 27/69 patients with blood group O, 45/96 patients with blood group A, 16/40 patients with blood group B and 5/22 patients with blood group AB. There was no statistically significant difference (P>0.05) in the incidence of HP infection between these groups (proving that HP infection did not depend upon the blood groups). Also, there was no significant correlation between the presence of particular blood group in HP+ patients related to the reported frequency of the blood groups in Serbian population (0--38%, A--42%, B--15%, AB--5%). HP was found in 16/36 Rh- and in 77/191 Rh+ patients without statistical difference (P>0.05). Also, there was no significant correlation of the presence of the Rh factor in the HP positive patients to the frequency of the Rh factor in the Serbian population (84% Rh+ and 16% Rh-). The basic value of the HP+ test was slightly, but not significantly lower in comparison to the HP- patients (P>0.05). On the contrary, test values showed a highly significant difference (P<0.01) in HP+ and HP- patients. In conclusion, in adults HP infection does not depend upon the patient's age, gender, blood group type or Rh factor. In clinical terms, there were 93 true positive (TP), 129 true negative (TN), 5 false negative (FN) and 0 false positive (FP) patients. Sensitivity of the method was 94.9%, specificity 100%, positive predictive value 100%, negative predictive value 96.3% and accuracy 97.8%.

• Authors: Milorad Petrović, Vera Artiko, Slavica Novosel, Tanja Ille, Dragana Šobić-Šaranović, Smiljana Pavlović, Emilija Jakšić, Mirjana Stojković, Andrija Antić, Vladimir Obradović
• Journal: Hellenic journal of nuclear medicine (Hell J Nucl Med) 2011 Jan-Apr Vol. 14 Issue 1 Pg. 21-4 ISSN: 1790-5427 [Print] Greece
• PMID: 21512660 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ABO Blood-Group System
• Carbon Radioisotopes
• Rh-Hr Blood-Group System
• Urea

Topics

• ABO Blood-Group System (metabolism)
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Breath Tests
• Carbon Radioisotopes
• Female
• Gastrointestinal Diseases (blood)
• Helicobacter Infections (blood, diagnosis)
• Helicobacter pylori (physiology)
• Humans
• Male
• Middle Aged
• Rh-Hr Blood-Group System (metabolism)
• Sex Factors
• Stomach (microbiology)
• Urea
• Young Adult