Abstract | AIM:
Thrombosis occurs in the coronary arteries via the activation of platelets, and leads to acute myocardial infarction and sudden death. Obovatol, a major biphenolic component of Magnolia Obovata leaves, displays anti-inflammatory and acyl Co-A cholesterol acyltrasferase inhibitory effects. The purpose of this study was to determine the effects of obovatol on thrombus formation in vivo and platelet activation in vitro and ex vivo. METHODS: We investigated the antiplatelet and antithrombotic activities of obovatol in rat carotid arterial thrombosis in vivo along with platelet aggregation in vitro and ex vivo. Its possible cellular mechanism of antiplatelet activity was investigated by testing PLC-γ2 activation, arachidonic acid cascade, calcium mobilization and granule secretion. RESULTS: CONCLUSION:
Obovatol has a potent antithrombotic effect, which may be due to antiplatelet activity. The antiplatelet activity of obovatol is mediated by inhibition of PLC-γ2 phosphorylation. Thus, obovatol may be a potential candidate to treat cardiovascular disease.
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Authors | Eun-Seok Park, Yong Lim, Seung-Ho Lee, Byoung-Mog Kwon, Hwan-Soo Yoo, Jin-Tae Hong, Yeo-Pyo Yun |
Journal | Journal of atherosclerosis and thrombosis
(J Atheroscler Thromb)
Vol. 18
Issue 8
Pg. 659-69
( 2011)
ISSN: 1880-3873 [Electronic] Japan |
PMID | 21512279
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biphenyl Compounds
- Phenyl Ethers
- Plant Extracts
- Phenol
- obovatol
- Phospholipase C gamma
- Calcium
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Topics |
- Administration, Oral
- Animals
- Arteries
(pathology)
- Biphenyl Compounds
(pharmacology)
- Calcium
(metabolism)
- Disease Models, Animal
- Humans
- Inhibitory Concentration 50
- Magnolia
(metabolism)
- Male
- Phenol
(chemistry)
- Phenyl Ethers
(pharmacology)
- Phospholipase C gamma
(metabolism)
- Phosphorylation
- Plant Extracts
(pharmacology)
- Platelet Aggregation
(drug effects)
- Rabbits
- Rats
- Rats, Sprague-Dawley
- Thrombosis
(drug therapy)
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