Severe mania complicating treatment of narcolepsy with cataplexy.

Abstract

We report the case of a 22-year-old male who exhibited severe manic behavior shortly after beginning treatment with modafinil and venlafaxine for narcolepsy with cataplexy. The manic episode persisted several weeks after medication cessation and required management with a mood stabilizer. Reinstitution of modafinil and an alternate antidepressant for recurrent sleepiness and cataplexy was well tolerated and very effective. Sleep physicians should be aware that psychostimulants, including modafinil, and antidepressant medications commonly prescribed for treatment of narcolepsy may precipitate mania in patients with underlying bipolar disorder.

• Authors: Mark I Crosby, David A Bradshaw, Robert N McLay
• Journal: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine (J Clin Sleep Med) Vol. 7 Issue 2 Pg. 214-6 (Apr 15 2011) ISSN: 1550-9397 [Electronic] United States
• PMID: 21509339 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antidepressive Agents, Second-Generation
• Benzhydryl Compounds
• Central Nervous System Stimulants
• Cyclohexanols
• Venlafaxine Hydrochloride
• Modafinil

Topics

• Antidepressive Agents, Second-Generation (administration & dosage, adverse effects, therapeutic use)
• Benzhydryl Compounds (adverse effects, therapeutic use)
• Bipolar Disorder (chemically induced)
• Central Nervous System Stimulants (administration & dosage, adverse effects, therapeutic use)
• Cyclohexanols (adverse effects, therapeutic use)
• Drug Therapy, Combination
• Humans
• Male
• Modafinil
• Narcolepsy (complications, drug therapy)
• Venlafaxine Hydrochloride
• Young Adult