Meningoencephalitis Due to HIV Replication Despite Plasmatic Viral Control.

Abstract

We report a symptomatic case of HIV replication in CSF (Cerebro Spinal Fluid) despite low plasmatic viral load. The patient, known HIV positive since 3 years, under HAART (Highly Active Antiretroviral therapy), presented an acute meningoencephalitis which was improved by optimization of treatment for a better CNS (Central Nervous System) penetration according to the CHARTER's (CNS HIV Antiretroviral Therapy Effects Research) score. CNS can be considered as a specific compartment for HIV replication and can be involved in acute or chronic neurologic impairment. As showed in this observation, CHARTER score could be helpful to optimize HAART penetration in CNS, but indication and use remain uncertain in current practice.

• Authors: Aurélien Dinh, Jérôme Salomon, Damien Le Du, Dominique Mathez, Robert Carlier, Louis Bernard, Pierre de Truchis
• Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) (J Int Assoc Physicians AIDS Care (Chic)) 2011 Nov-Dec Vol. 10 Issue 6 Pg. 345-8 ISSN: 1557-0886 [Electronic] United States
• PMID: 21508294 (Publication Type: Journal Article)

Chemical References

• Anti-HIV Agents

Topics

• Anti-HIV Agents (therapeutic use)
• Antiretroviral Therapy, Highly Active
• HIV Infections (drug therapy)
• HIV-1
• Humans
• Meningoencephalitis
• Viral Load