Abstract | OBJECTIVES: METHODS: In the present study, constipation was induced in female Sprague-Dawley rats by diphenoxylate, and the prebiotics dissolved in milk were used as an intervention. The indicators of intestinal peristalsis, including the time of passing black stool initially, the grains of black stool in 24 hours, and the advance rate of ponceau, were measured. The content of intestinal sIgA was detected by enzyme-linked immunosorbent assay. The contents of SOD and MDA in serum and intestinal tissue were analyzed by their detection kits. RESULTS: The changes in intestinal peristalsis show obvious constipation. The content of intestinal sIgA decreases, the content of SOD decreases, but the content of MDA increases in constipated rats. Prebiotics can attenuate the constipation-caused abnormal indicators significantly. CONCLUSIONS:
Prebiotics can attenuate decreased intestinal immunity and enhanced oxidative stress, in addition to reduced intestinal peristalsis and of the constipated rats.
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Authors | Yanning Li, Yanhong Zong, Jinsheng Qi, Kun Liu |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 53
Issue 4
Pg. 447-52
(Oct 2011)
ISSN: 1536-4801 [Electronic] United States |
PMID | 21505362
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin A, Secretory
- Prebiotics
- Malondialdehyde
- Diphenoxylate
- Superoxide Dismutase
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Topics |
- Animals
- Constipation
(chemically induced, drug therapy)
- Diphenoxylate
(metabolism)
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Female
- Immunoglobulin A, Secretory
(analysis)
- Intestinal Mucosa
(metabolism)
- Intestines
(drug effects)
- Malondialdehyde
(blood)
- Oxidative Stress
(drug effects)
- Prebiotics
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(blood)
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