[Long-term effects of indapamide in left ventricular hypertrophy in patients with hypertension].

Abstract

Left ventricular hypertrophy is a major and independent cardiovascular risk factor in hypertension. The effects of a diuretic, indapamide, on the regression of left ventricular hypertrophy were studied in a group of 9 patients with mild hypertension treated in an open therapeutic trial over a 12 month period. At the end of the trial, the left ventricular mass index decreased significantly from 172 +/- 11 to 147 +/- 11 g/m2 (p less than 0.001). Therefore, in contrast to the other diuretics which have been studied, indapamide seems able to induce regression of the left ventricular hypertrophy complicating hypertension.

• Authors: M Komajda, K Klimczak, J Evans, B Boutin, F Brackman, D Guez, Y Grosgogeat
• Journal: Archives des maladies du coeur et des vaisseaux (Arch Mal Coeur Vaiss) Vol. 83 Spec No 4 Pg. 45-50 (Dec 1990) ISSN: 0003-9683 [Print] France
• Vernacular Title: Effets à long terme de l'indapamide sur l'hypertrophie ventriculaire gauche de l'hypertendu.
• PMID: 2150474 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Indapamide

Topics

• Adult
• Aged
• Cardiomegaly (drug therapy, etiology)
• Drug Evaluation
• Female
• Humans
• Hypertension (complications, drug therapy)
• Indapamide (therapeutic use)
• Male
• Middle Aged
• Time Factors