[Extracorporeal cardiac shock wave therapy improved myocardial micro-vascular circulation after acute myocardial infarction at early stage in pigs].

Abstract

OBJECTIVE:

To explore the effect of low-energy extracorporeal shock wave therapy to improve myocardial micro-vascular circulation after acute myocardial infarction at the early stage in pig model.

METHODS:

A total of 25 domestic pigs were used in this study. Model of acute myocardial infarction (AMI) was created successfully by the implantation of angioplasty balloon in mid-distal segment of left anterior descending coronary artery (n=20). These AMI animals were divided two groups. Extracorporeal shock wave therapy to the ischemic myocardial region was performed for the group of shock wave therapy (n=15) at 3 days after acute myocardial infarction; The remaining AMI animals were treated in the same manner, but without the shock wave therapy (n=5), The other health animals (n=5) were used as blank control group. The number of endothelium cell, capillary density, VEGF mRNA level and collateral vessel Rentrop score in each group were evaluated and compared.

RESULTS:

Shock wave treatment up-regulated the mRNA expression of VEGF in the model of acute myocardial infarction (P < 0.05). Furthermore, the number of capillaries was significantly higher in the shock wave group than that of positive and blank control group (P < 0.05). The Rentrop score of collateral vessel indicated the reconstruction of collateral circulation in shock wave group.

CONCLUSION:

Extracorporeal cardiac shock wave therapy could effectively induce angiogenesis, up-regulate the expression of angiogenic factor, resulting in an improvement in micro-vascular circulation reconstruction of ischemic myocardial region.

• Authors: Si-ming Tao, Tao Guo, Yue Wang, Hong-yan Cai, Chao Yang
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 42 Issue 2 Pg. 222-6 (Mar 2011) ISSN: 1672-173X [Print] China
• PMID: 21500558 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• Vascular Endothelial Growth Factor A

Topics

• Animals
• Coronary Vessels (physiopathology, radiation effects)
• Disease Models, Animal
• High-Energy Shock Waves (therapeutic use)
• Microcirculation (radiation effects)
• Myocardial Infarction (therapy)
• Neovascularization, Physiologic (radiation effects)
• RNA, Messenger (genetics, metabolism)
• Swine
• Time Factors
• Vascular Endothelial Growth Factor A (genetics, metabolism)