Abstract | BACKGROUND: Intravenous glutamine-enriched solution seems to be effective in posttransplant period in decreasing the severity and duration of mucositis. The aim of this randomized study was to determine the benefit of glutamine supplementation both on mucosal morbidity and in posttransplant associated complications. METHODS: RESULTS: One hundred twenty consecutive patients (83 men; median age, 8.1 years) were enrolled. The mean duration of treatment was 23.5 and 23 days in the two treatment arms. The mean calorie intake was 1538 kcal/d in the S-TPN group and 1512 kcal/d in GE-TPN group. All patients were well nourished before and after HSCT. Mucositis occurred in 91.4% and 91.7% of patients in S-TPN and GE-TPN arm, respectively (P=0.98). Odds ratio adjusted by type of HSCT was 0.98 (95% confidence interval, 0.26-2.63). Type and duration of analgesic treatment, clinical outcome (engraftment, graft versus host disease, early morbidity, and mortality, relapse rate up to 180 days post-HSCT) were not significantly different in the two treatment arms. CONCLUSION: GE-TPN solution does not affect mucositis and outcome in well-nourished HSCT allogeneic patients.
|
Authors | Cornelio Uderzo, Paola Rebora, Emanuela Marrocco, Stefania Varotto, Francesca Cichello, Maurizio Bonetti, Natalia Maximova, Davide Zanon, Franca Fagioli, Francesca Nesi, Riccardo Masetti, Roberto Masetti, Attilio Rovelli, Roberto Rondelli, Maria Grazia Valsecchi, Simone Cesaro |
Journal | Transplantation
(Transplantation)
Vol. 91
Issue 12
Pg. 1321-5
(Jun 27 2011)
ISSN: 1534-6080 [Electronic] United States |
PMID | 21499196
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
|
Topics |
- Adolescent
- Analgesia
(methods)
- Child
- Child, Preschool
- Double-Blind Method
- Female
- Glutamine
(metabolism, therapeutic use)
- Hematopoietic Stem Cell Transplantation
(methods)
- Humans
- Infant
- Male
- Mucositis
(diagnosis, etiology)
- Mucous Membrane
(pathology)
- Neoplasms
(therapy)
- Odds Ratio
- Parenteral Nutrition
- Prospective Studies
- Recurrence
- Stem Cells
(cytology)
- Treatment Outcome
|