Abstract | PURPOSE: METHODS: A retrospective review of all eyes treated with stereotactic fractionated external beam radiation (20-40 Gy, 2-Gy fractions) between 1997 and 2000 was performed to identify eyes with ≥ 2-year follow-up for analysis. A subset was imaged prospectively using a high-resolution Fourier-domain optical coherence tomography. RESULTS: Among 94 eyes treated, 33 eyes (32 subjects) had ≥ 2-year follow-up information (mean follow-up, 6.2 years; range, 2-10 years). Final visual acuity ranged from 20/50 to no light perception. Final macular findings included central geographic atrophy (49%), disciform scar (30%), and active choroidal neovascular membrane (9%). Fourier-domain optical coherence tomography images of three eyes with geographic atrophy revealed photoreceptor layer loss within areas of geographic atrophy with intact retinal morphology in areas of radiation exposure outside geographic atrophy. Radiation retinopathy was suspected in 18% and confirmed by fluorescein angiography in 15%, ranging from mild to neovascular glaucoma/phthisis bulbi (2 eyes). Mean time from stereotactic fractionated external beam radiation to development of radiation retinopathy was 5.4 years (range, 1-10 years). CONCLUSION:
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Authors | Rupan Trikha, Lawrence S Morse, Robert J Zawadzki, John S Werner, Susanna S Park |
Journal | Retina (Philadelphia, Pa.)
(Retina)
2011 Jul-Aug
Vol. 31
Issue 7
Pg. 1303-15
ISSN: 1539-2864 [Electronic] United States |
PMID | 21499195
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Aged, 80 and over
- Choroidal Neovascularization
(diagnosis, radiotherapy)
- Dose Fractionation, Radiation
- Female
- Fluorescein Angiography
- Follow-Up Studies
- Fourier Analysis
- Geographic Atrophy
(diagnosis, etiology)
- Humans
- Macular Degeneration
(diagnosis, radiotherapy)
- Male
- Middle Aged
- Photoreceptor Cells, Vertebrate
(radiation effects)
- Radiation Dosage
- Radiation Injuries
(diagnosis, etiology)
- Radiotherapy
(adverse effects)
- Retrospective Studies
- Stereotaxic Techniques
- Time Factors
- Tomography, Optical Coherence
- Visual Acuity
(physiology)
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