Abstract | PURPOSE: MATERIALS AND METHODS: This case-control analysis within the Nashville Men's Health Study included men recruited at prostate biopsy. Body morphometrics, health history and urine were collected from more than 2,000 men before biopsy. F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. Multivariable linear and logistic regression was used to determine the associations between F2-isoprostane level, and high grade prostatic intraepithelial neoplasia and prostate cancer. RESULTS: CONCLUSIONS:
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Authors | Daniel A Barocas, Saundra Motley, Michael S Cookson, Sam S Chang, David F Penson, Qi Dai, Ginger Milne, L Jackson Roberts 2nd, Jason Morrow, Raoul S Concepcion, Joseph A Smith Jr, Jay H Fowke |
Journal | The Journal of urology
(J Urol)
Vol. 185
Issue 6
Pg. 2102-7
(Jun 2011)
ISSN: 1527-3792 [Electronic] United States |
PMID | 21496850
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Case-Control Studies
- F2-Isoprostanes
(urine)
- Humans
- Male
- Oxidative Stress
- Prostatic Intraepithelial Neoplasia
(metabolism, urine)
- Prostatic Neoplasms
(metabolism, urine)
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