Abstract |
We reported recently that intracerebral administration of NMO- IgG with human complement produces neuromyelitis optica (NMO) lesions in mice. We examined the role of T cells in the formation of NMO lesions by comparing brain histopathology in wildtype and nude mice. Brains were co-injected with IgG from NMO patients and human complement. At 24h and 5days, wildtype vs. nude mouse brains had comparable inflammation (CD45 immunoreactivity), loss of myelin ( Luxol Fast Blue staining) and loss of AQP4 immunoreactivity. We conclude that T cells are not required for the formation of NMO lesions in this mouse model.
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Authors | Samira Saadoun, Patrick Waters, Claire Macdonald, Leslie R Bridges, B Anthony Bell, Angela Vincent, A S Verkman, Marios C Papadopoulos |
Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 235
Issue 1-2
Pg. 27-32
(Jun 2011)
ISSN: 1872-8421 [Electronic] Netherlands |
PMID | 21492943
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- Immunoglobulin G
- Complement System Proteins
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Topics |
- Animals
- Brain
(immunology, pathology)
- Complement System Proteins
(administration & dosage)
- Humans
- Immunoglobulin G
(administration & dosage)
- Immunologic Deficiency Syndromes
(immunology, pathology)
- Injections, Intraventricular
- Mice
- Mice, Knockout
- Mice, Nude
- Neuromyelitis Optica
(immunology, pathology)
- T-Lymphocytes
(immunology, pathology)
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