HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Practical immunoregulation: neonatal immune response variation and prophylaxis of experimental food allergy in pigs.

Abstract
The importance of environment in immune response is identified and the increase in prevalence of allergic, autoimmune and chronic inflammatory diseases reviewed. In particular, altered opportunity to acquire evolutionarily anticipated commensal microbiota is associated through the "hygiene hypothesis" with defective developmental and response signals to the innate and adaptive immune systems. Evidence of the detrimental effects of such environments is reviewed as is evidence for remediation using controlled exposure to bacteria or their active components such as LPS or peptidoglycan ligands for TLR and NOD-like receptors. Occurrence of major environmentally associated changes in porcine immune response phenotype are described. The prophylactic effects of heat-killed Escherichia coli given intramuscularly or of oral Lactococcus lactis on experimental ovomucoid-induced allergy in piglets are described in the context of altered immune response bias favouring reduced type-2 phenotypes. The high frequency of clinical tolerance to developing allergic signs even in the face of classical sensitization indicates possible function in this pig model of regulatory effectors such as Treg cells.
AuthorsBruce N Wilkie, Prithy Rupa, Julie Schmied
JournalVeterinary immunology and immunopathology (Vet Immunol Immunopathol) Vol. 148 Issue 1-2 Pg. 110-5 (Jul 15 2012) ISSN: 1873-2534 [Electronic] Netherlands
PMID21489640 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2011 Elsevier B.V. All rights reserved.
Topics
  • Animals
  • Animals, Newborn (immunology, microbiology)
  • Escherichia coli (immunology)
  • Food Hypersensitivity (immunology, prevention & control, veterinary)
  • Hygiene Hypothesis
  • Lactobacillus (immunology)
  • Swine (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: