Periodontal disease in adults with untreated congenital growth hormone deficiency: a case-control study.

Abstract

AIM:

The aim of this study was to investigate the possible associations between isolated growth hormone deficiency (IGHD) and periodontal attachment loss (PAL) in adults affected by congenital IGHD.

MATERIALS AND METHODS:

Forty-five previously identified IGHD subjects were eligible for this study. The final study sample comprised 32 cases (gender:20M/12F; age:44.8 ± 17.5) matched for age, gender, diabetes, smoking status and income to 32 controls (non-IGHD subjects). Participants were submitted to a full-mouth clinical examination of six sites per tooth and were interviewed using a structured, written questionnaire. Periodontitis was defined as proximal PAL≥5 mm affecting ≥30% of teeth.

RESULTS:

No significant differences were observed in the percentage of sites with visible plaque between IGHD and non-IGHD subjects (59.4% versus 46.9%, p=0.32). IGHD subjects had significant less supragingival calculus (31.3% versus 59.4%, p=0.02) and more bleeding on probing (71.9% versus 18.8%, p<0.01) than controls. PAL≥5 mm was significantly more prevalent (100% versus 71.9%, p<0.01) and affected more teeth (30.5% versus 6.7%, p<0.01) in cases than in controls. After adjusting for supragingival calculus, IGHD cases had a higher likelihood of having periodontitis than controls (OR=17.4-17.8, 95% CI=2.3-134.9, p=0.004-0.005).

CONCLUSION:

Congenital IGHD subjects have a greater chance of having PAL.

• Authors: Isabella M P Araujo Britto, Manuel H Aguiar-Oliveira, Luiz A Oliveira-Neto, Roberto Salvatori, Anita H Oliveira Souza, Vanessa Porto Araujo, Priscila Corraini, Claudio Mendes Pannuti, Giuseppe Alexandre Romito, Francisco Emílio Pustiglioni
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 38 Issue 6 Pg. 525-31 (Jun 2011) ISSN: 1600-051X [Electronic] United States
• PMID: 21488932 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 John Wiley & Sons A/S.

Chemical References

• Receptors, Neuropeptide
• Receptors, Pituitary Hormone-Regulating Hormone
• somatotropin releasing hormone receptor

Topics

• Adult
• Brazil
• Case-Control Studies
• Dwarfism, Pituitary (complications, congenital)
• Female
• Genetic Predisposition to Disease
• Humans
• Logistic Models
• Male
• Middle Aged
• Pedigree
• Periodontal Attachment Loss (etiology, genetics)
• Periodontitis (etiology, genetics)
• Receptors, Neuropeptide (genetics)
• Receptors, Pituitary Hormone-Regulating Hormone (genetics)
• Smoking
• Surveys and Questionnaires
• Young Adult