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Evaluation of safety of lipomer doxycycline hydrochloride (lipomer DH).

Abstract
The nanoparticulate formulation of lipomer doxycycline hydrochloride (lipomer DH) has been synthesized for the treatment of Brucellosis to increase efficacy of the drug. The present study was undertaken to determine the intravenous safety of blank lipomer and Lipomer DH in terms of maximum tolerated dose in rats. It was observed that blank lipomer and lipomer DH were safe when administered intravenously at doses 2000 mg/kg Bw and 18 mg/kg bw respectively.
AuthorsRohit Dhumal, Mahesh Soni, Padma Devarajan, Abdul Samad, Rajiv Gaikwad, Geeta Vanage
JournalJournal of biomedical nanotechnology (J Biomed Nanotechnol) Vol. 7 Issue 1 Pg. 146-7 (Feb 2011) ISSN: 1550-7033 [Print] United States
PMID21485844 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Liposomes
  • Doxycycline
Topics
  • Animals
  • Anti-Bacterial Agents (administration & dosage, adverse effects, chemistry)
  • Doxycycline (chemistry, toxicity)
  • Lethal Dose 50
  • Liposomes (chemistry, toxicity)
  • Rats
  • Survival Analysis
  • Survival Rate

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