CNS depressant activities of roots of Coccos nucifera in mice.

Abstract

The ethanol extract of Coccos nucifera (EECN) was tested for possible pharmacological effects on experimental animals. EECN significantly potentiated the sleeping time of mice induced by standard hypnotics viz. pentobarbital sodium, diazepam, and meprobamate in a dose dependent manner. EECN showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with EECN caused significant protection against pentylenetetrazole-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the ethanol extract of C. nucifera.

• Authors: Dilipkumar Pal, Abhijit Sarkar, Sumanta Gain, Sandip Jana, Soumit Mandal
• Journal: Acta poloniae pharmaceutica (Acta Pol Pharm) Vol. 68 Issue 2 Pg. 249-54 ( 2011) ISSN: 0001-6837 [Print] Poland
• PMID: 21485298 (Publication Type: Journal Article)

Chemical References

• Analgesics
• Anticonvulsants
• Central Nervous System Depressants
• Hypnotics and Sedatives
• Plant Extracts
• Solvents
• Ethanol
• Acetic Acid
• Pentylenetetrazole

Topics

• Acetic Acid
• Analgesics (pharmacology)
• Animals
• Anticonvulsants (pharmacology)
• Behavior, Animal (drug effects)
• Central Nervous System Depressants (pharmacology, toxicity)
• Cocos
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Ethanol (chemistry)
• Female
• Hypnotics and Sedatives (pharmacology)
• Lethal Dose 50
• Male
• Mice
• Pain (chemically induced, prevention & control)
• Pentylenetetrazole
• Plant Extracts (pharmacology, toxicity)
• Plant Roots
• Seizures (chemically induced, prevention & control)
• Sleep (drug effects)
• Solvents (chemistry)