Abstract |
A 79-year-old man with diabetes mellitus developed prolonged hypoglycemia. The patient had ingested two Chinese dietary supplements in addition to his prescribed nateglinide ( Fastic). Using liquid chromatography tandem mass spectrometry, glimepiride from sulfonylurea, as well as rosiglitazone from a thiazolidine derivative, were detected in the Chinese dietary supplements, which were then quantitatively analyzed using liquid chromatography with UV detector. Mean values (n=3) of glimepiride contents of the Chinese dietary supplements were 0.75 and 0.86 mg/ capsule. Predicted intake of glimepiride in the patient was estimated to be 4.8-8.2 mg/day according to the glimepiride contents and directions of the Chinese dietary supplements. The daily intake of glimepiride in this patient was greater than daily maintenance doses (1-4 mg) of glimepiride for diabetic patients. Therefore, overdose of glimepiride by ingestion of the Chinese dietary supplements appears to be associated with the development of prolonged hypoglycemia.
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Authors | Yuji Fujita, Hiroyuki Honma, Jo Satoh, Yasuhisa Fujino, Makoto Onodera, Yoshihiro Inoue, Shigeatsu Endo |
Journal | Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology
(Chudoku Kenkyu)
Vol. 24
Issue 1
Pg. 51-6
(Mar 2011)
ISSN: 0914-3777 [Print] Japan |
PMID | 21485125
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Hypoglycemic Agents
- Sulfonylurea Compounds
- Thiazolidinediones
- Rosiglitazone
- glimepiride
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Topics |
- Aged
- China
- Chromatography, Liquid
- Dietary Supplements
(adverse effects, analysis)
- Drug Overdose
- Humans
- Hypoglycemia
(chemically induced)
- Hypoglycemic Agents
(adverse effects, analysis)
- Male
- Rosiglitazone
- Sulfonylurea Compounds
(adverse effects, analysis)
- Tandem Mass Spectrometry
- Thiazolidinediones
(adverse effects, analysis)
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