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[Detection of glimepiride and rosiglitazone from Chinese dietary supplements].

Abstract
A 79-year-old man with diabetes mellitus developed prolonged hypoglycemia. The patient had ingested two Chinese dietary supplements in addition to his prescribed nateglinide (Fastic). Using liquid chromatography tandem mass spectrometry, glimepiride from sulfonylurea, as well as rosiglitazone from a thiazolidine derivative, were detected in the Chinese dietary supplements, which were then quantitatively analyzed using liquid chromatography with UV detector. Mean values (n=3) of glimepiride contents of the Chinese dietary supplements were 0.75 and 0.86 mg/capsule. Predicted intake of glimepiride in the patient was estimated to be 4.8-8.2 mg/day according to the glimepiride contents and directions of the Chinese dietary supplements. The daily intake of glimepiride in this patient was greater than daily maintenance doses (1-4 mg) of glimepiride for diabetic patients. Therefore, overdose of glimepiride by ingestion of the Chinese dietary supplements appears to be associated with the development of prolonged hypoglycemia.
AuthorsYuji Fujita, Hiroyuki Honma, Jo Satoh, Yasuhisa Fujino, Makoto Onodera, Yoshihiro Inoue, Shigeatsu Endo
JournalChudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology (Chudoku Kenkyu) Vol. 24 Issue 1 Pg. 51-6 (Mar 2011) ISSN: 0914-3777 [Print] Japan
PMID21485125 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Hypoglycemic Agents
  • Sulfonylurea Compounds
  • Thiazolidinediones
  • Rosiglitazone
  • glimepiride
Topics
  • Aged
  • China
  • Chromatography, Liquid
  • Dietary Supplements (adverse effects, analysis)
  • Drug Overdose
  • Humans
  • Hypoglycemia (chemically induced)
  • Hypoglycemic Agents (adverse effects, analysis)
  • Male
  • Rosiglitazone
  • Sulfonylurea Compounds (adverse effects, analysis)
  • Tandem Mass Spectrometry
  • Thiazolidinediones (adverse effects, analysis)

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