[Sulglicotide in the treatment of dyspeptic patients with duodenogastric reflux].

Abstract

The therapeutic efficacy of sulglicotide was tested in an open study of dyspeptic patients suffering from proven duodenogastric reflux. Twenty outpatients with non-ulcer dyspepsia and alkaline reflux demonstrated by measurement of enterogastric flux were enrolled in the study. All patients could be evaluated at the end of 8 weeks' treatment with 200 mg sulglicotide t.i.d. This treatment did not cause any change for the better of alkaline reflux but did induce marked improvement of subjective symptoms (p less than 0.05 vs baseline), giving the impression that in spite of the continued presence of the damaging agent the drug had reduced the mucosal lesion by increasing gastro-protective capacity.

• Authors: M Bertoldi, S Bigliazzi, S Taddeucci, G Cangioni, M Psilogenis
• Journal: La Clinica terapeutica (Clin Ter) 1990 Aug 15-31 Vol. 134 Issue 3-4 Pg. 211-5 ISSN: 0009-9074 [Print] Italy
• Vernacular Title: Sulglicotide nel trattamento di pazienti dispeptici affetti da reflusso duodenogastrico.
• PMID: 2147623 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Sialoglycoproteins
• sulglicotide

Topics

• Adult
• Anti-Ulcer Agents (administration & dosage, therapeutic use)
• Drug Evaluation
• Duodenogastric Reflux (complications, drug therapy)
• Dyspepsia (complications, drug therapy)
• Female
• Humans
• Male
• Sialoglycoproteins (administration & dosage, therapeutic use)
• Time Factors