[Dose-effect of beta-sitosterin in type IIa and IIb hypercholesterolemias (author's transl)].

Abstract

In a trial with 59 outpatients with hypercholesterolemia the effect of two different doses of 5.28 and 10,56 g Beta-Sitosterol was compared to placebo. Each treatment phase lasted six weeks. Serum cholesterol decreased on the average under Beta-Sitosterol by 10--13% (p less than 0.05) in correlation with LDL. The triglycerides were not affected; there was a slight increase in the HDL/LDL quotient. The optimal daily dose of Beta-Sitosterol was about 6 gm; the double dose was no more effective.

• Authors: W Schwartzkopff, H J Jantke
• Journal: MMW, Munchener medizinische Wochenschrift (MMW Munch Med Wochenschr) Vol. 120 Issue 47 Pg. 1575-8 (Nov 24 1978) ISSN: 0341-3098 [Print] Germany
• Vernacular Title: Dosiswirksamkeit von ss-Sitosterin bei Hypercholesterinämien der Typen IIa und IIb.
• PMID: 214701 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Lipoproteins, HDL
• Lipoproteins, LDL
• Sitosterols
• Triglycerides

Topics

• Aged
• Dose-Response Relationship, Drug
• Female
• Humans
• Hypercholesterolemia (drug therapy)
• Lipoproteins, HDL
• Lipoproteins, LDL
• Male
• Middle Aged
• Sitosterols (therapeutic use)
• Triglycerides