Abstract |
Preliminary examination for the structure-activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggested that 2-aryl-6,7-methylenedioxy-1,4-naphthoquinone-1-oxime methyl ethers, carrying 2-methoxy-4,5-methylenedioxyphenyl, 7-methoxy-2-methylbenzofuran-4-yl, and 2-methoxycarbonyl-3,4-dimethoxyphenyl as the 2-aryl substituent, were potential candidates for anti- cancer drugs.
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Authors | Tsutomu Ishikawa, Tatsuru Saito, Ayako Kurosawa, Toshiko Watanabe, Sakiko Maruyama, Yuh-ichiro Ichikawa, Ryota Yamada, Hiroko Okuzawa, Hiromi Sato, Koichi Ueno |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 59
Issue 4
Pg. 472-5
( 2011)
ISSN: 1347-5223 [Electronic] Japan |
PMID | 21467676
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Methyl Ethers
- Naphthoquinones
- Oximes
- 1,4-naphthoquinone
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Topics |
- Antineoplastic Agents
(chemistry, isolation & purification, toxicity)
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Humans
- Methyl Ethers
(chemistry)
- Naphthoquinones
(chemistry, toxicity)
- Oximes
(chemistry, toxicity)
- Structure-Activity Relationship
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