Insulin resistance influences weight loss in non-obese women who followed a home-based exercise program and slight caloric restriction.

Abstract

This study aimed to evaluate the influence of insulin resistance status on weight changes in non-obese women who followed a home-based exercise program and slight caloric restriction over a period of 12 months. Middle-aged (25-45 year), non-obese (body mass index of 23-29.9 kg/m(2)) women were randomly assigned to control (CG) or home-based exercise group (HB). The HB group received a booklet explaining the physical exercises to be practiced at home at least three times per week (40 min/session). Both groups were required to follow a small energy restriction of 100-300 calories per day. For the analysis, women were stratified in two groups according to baseline insulin sensitivity: NIR (non-insulin resistant; n = 121) and IR (insulin resistant; n = 64). Women classified as IR at baseline had greater weight loss after 12 months of follow-up (-1.6 kg vs. -1.1 kg; p = 0.01), and HB exercise helped to reduce weight only among NIR women (-1.5 vs. -0.7; p = 0.04); no differences were observed between intervention groups for IR women (-1.5 vs. -1.7; p = 0.24). There were no differences between IR and NIR groups for lipid profile after adjustment for weight changes. Insulin resistance facilitated weight loss, and home-based exercise promoted greater weight loss only in non-insulin resistance women.

• Authors: Mauro Felippe Felix Mediano, Rosely Sichieri
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 92 Issue 3 Pg. 361-7 (Jun 2011) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 21466903 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Topics

• Adult
• Caloric Restriction
• Exercise Therapy (methods)
• Female
• Humans
• Insulin Resistance (physiology)
• Middle Aged
• Weight Loss (physiology)