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Glucocorticoids in the treatment of neonatal meconium aspiration syndrome.

Abstract
Meconium aspiration syndrome is a serious neonatal disease with complex pathophysiology. With respect to the contribution of meconium-induced lung edema, inflammation and vasoconstriction on the course of the disease, glucocorticoids are increasingly used in the treatment of MAS despite the fact that principal questions on the choice of GCs derivative, mode of delivery and dosing have not been answered yet. To bring a complex insight into the topic, this article reviews the pathomechanisms of MAS, mechanisms of action of GCs, as well as the advantages and disadvantages of GCs administration in experimental models and newborns with MAS.
AuthorsDaniela Mokra, Juraj Mokry
JournalEuropean journal of pediatrics (Eur J Pediatr) Vol. 170 Issue 12 Pg. 1495-505 (Dec 2011) ISSN: 1432-1076 [Electronic] Germany
PMID21465122 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Glucocorticoids
Topics
  • Glucocorticoids (therapeutic use)
  • Humans
  • Infant, Newborn
  • Meconium Aspiration Syndrome (drug therapy)
  • Treatment Outcome

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