A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: superior sagittal sinus thrombosis.

Abstract

We report the case of a 4-year-old boy with acute lymphoblastic leukemia in high-risk group who suffered from generalized tonic-colonic seizure evolving into status epilepticus, and subsequent left hemiparesis during his first reinduction chemotherapy, consisting of dexamethasone, vincristine, l-asparaginase, and epirubicin. Superior sagittal sinus and cerebral venous thrombosis, predominantly in right side, were proved by brain magnetic resonance imaging. After aggressive treatment with low-molecular weight heparin (LMWH), left hemiparesis improved in 1 week. And he was fully ambulatory 3 weeks later. The second cycle of reinduction chemotherapy was conducted smoothly with the concomitant use of LMWH. This case illustrates the strong correlation of the rare thrombotic complication, superior sagittal sinus thrombosis, and hypercoagulable status secondary to combination use of l-asparaginase and corticosteroid. Early and vigilant recognition of superior sagittal sinus thrombosis and prompt anticoagulation with LMWH may prevent further neurological damage.

• Authors: Ting-Yao Wang, Hsiu-Ju Yen, Giun-Yi Hung, Ming-Yun Hsieh, Ren-Bin Tang
• Journal: Journal of the Chinese Medical Association : JCMA (J Chin Med Assoc) Vol. 74 Issue 4 Pg. 183-7 (Apr 2011) ISSN: 1728-7731 [Electronic] Netherlands
• PMID: 21463850 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011. Published by Elsevier B.V.

Chemical References

• Heparin, Low-Molecular-Weight
• Asparaginase

Topics

• Asparaginase (adverse effects)
• Child, Preschool
• Heparin, Low-Molecular-Weight (therapeutic use)
• Humans
• Male
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications, drug therapy)
• Sagittal Sinus Thrombosis (drug therapy, etiology)