Evaluation of: Boudousq V, Ricaud S, Garambois V et al.: Brief intraperitoneal
radioimmunotherapy of small
peritoneal carcinomatosis using high activities of noninternalizing (125)I-labeled
monoclonal antibodies. J. Nucl. Med. 51, 1748-1755 (2010).
Mesothelioma,
pseudomyxoma peritonei, ovarian and
colon cancers, and several other
malignancies produce
peritoneal carcinomatosis in their advanced stages. This condition is typically managed with curative intention by means of a radical
cytoreductive surgery and
intraperitoneal hyperthermic chemotherapy. The method has been shown to improve the survival of some patients with peritoneal dissemination. However, the intracavitary instillation of
chemotherapy results in a nonuniform
drug distribution and allows penetration of the
drug only into the outermost layer of the
cancer nodule. Authors of the current study demonstrate that (125)I-radiolabeled
monoclonal antibody, 35A7, which recognizes anti-
carcinoembryonic antigen, can be used effectively and safely with low toxicity in the
therapy of small volume
peritoneal carcinomatosis after
cytoreductive surgery.