Abstract | SCOPE: To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression. METHODS AND RESULTS: CONCLUSION: In mice fed with a Western diet, chronic dietary intake of quercetin reduces liver fat accumulation and improves systemic parameters related to metabolic syndrome, probably mainly through decreasing oxidative stress and reducing PPARα expression, and the subsequent reduced expression in the liver of genes related to steatosis.
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Authors | Masuko Kobori, Saeko Masumoto, Yukari Akimoto, Hideaki Oike |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 55
Issue 4
Pg. 530-40
(Apr 2011)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 21462320
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- PPAR alpha
- RNA, Messenger
- Sterol Regulatory Element Binding Protein 1
- Thiobarbituric Acid Reactive Substances
- Triglycerides
- Quercetin
- Glutathione
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Topics |
- Adiposity
- Animals
- Diet
(adverse effects)
- Fatty Liver
(etiology, prevention & control)
- Gene Expression Regulation
- Glutathione
(metabolism)
- Liver
(metabolism, pathology)
- Male
- Metabolic Syndrome
(etiology, prevention & control)
- Mice
- Mice, Inbred C57BL
- Obesity
(metabolism, pathology, physiopathology, prevention & control)
- Oxidative Stress
- PPAR alpha
(genetics, metabolism)
- Quercetin
(therapeutic use)
- RNA, Messenger
- Sterol Regulatory Element Binding Protein 1
(genetics, metabolism)
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Time Factors
- Triglycerides
(metabolism)
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