[Atrial natriuretic peptide. II. Pathophysiology and possible clinical significance. Review].

Abstract

The heart atrium, as well as under certain pathophysiological conditions the ventricle, synthesize and release ANP. Exerting natriuretic, diuretic and vasorelaxant effects, this peptide plays an important role in the body's blood volume and blood pressure homeostasis. Whereas the pharmacological actions of ANP have been quite convincingly demonstrated, its physiological and pathophysiological role is less well defined. ANP plasma levels tend to be increased in diseases with salt and water retention, such as essential hypertension, congestive heart failure, renal failure or liver cirrhosis. With regard to its hemodynamic effects, ANP seems to be beneficial in patients with hypertension. ANP appears to have little therapeutic potential as a diuretic in patients with congestive heart failure and liver cirrhosis, possibly due to the decreased renal responsiveness to ANP in these diseases. However, ANP might to be a valuable therapeutic agent in acute renal failure.

• Authors: A M Vollmar
• Journal: Tierarztliche Praxis (Tierarztl Prax) Vol. 18 Issue 4 Pg. 319-22 (Aug 1990) ISSN: 0303-6286 [Print] Germany
• Vernacular Title: Das atriale natriuretische Peptid. Teil II: Pathophysiologie und mögliche klinische Bedeutung. Ubersicht.
• PMID: 2145657 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Atrial Natriuretic Factor

Topics

• Animals
• Atrial Natriuretic Factor (physiology, therapeutic use)
• Blood Pressure (physiology)
• Blood Volume (physiology)
• Heart Failure (physiopathology)
• Homeostasis
• Humans
• Hypertension (physiopathology)
• Kidney Diseases (physiopathology)
• Liver Diseases (physiopathology)