[HLA-associated predisposition to dilated cardiomyopathy].

Abstract

HLA-antigens grade I and II were studied by tissue typing in 60 Russians and 40 Georgians suffering from dilated cardiomyopathy (DCMP), and 40 Georgians with virus myocarditis. 267 test-donors Russians and 579 Georgians served as control. Markers of DCMP predisposition were found different for Russians and Georgians: DR4 (relative risk 2.96) and A11 (RR = 3.07), R12 (RR = 5.5), respectively. Georgians have a marker of resistance to DCMP--B35 (RR = 0.15). Antigen B12 marks a severe DCMP course in Georgians. Markers of virus myocarditis predisposition were distinct from those of DCMP: A1 (RR = 3.78) and B27 (RR = 3.62). This shows different etiology of the two diseases. The conclusion is made on nonidentical genetic markers of predisposition and resistance to the same disease in various populations.

• Authors: I S Polianskaia, L P Alekseev, V B Chumburidze, A P Iurenev, M G Guniia, P B Dubov, A G Dolbin
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 68 Issue 6 Pg. 30-3 (Jun 1990) ISSN: 0023-2149 [Print] Russia (Federation)
• Vernacular Title: Assotsirovannaia s HLA predraspolozhennost' k dilatatsionnoĭ kardiomiopatii.
• PMID: 2145467 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• HLA Antigens
• HLA-A Antigens
• HLA-B Antigens
• HLA-DR4 Antigen

Topics

• Cardiomyopathy, Dilated (etiology, genetics, immunology)
• Disease Susceptibility
• Gene Frequency (genetics)
• Georgia (Republic)
• HLA Antigens (genetics)
• HLA-A Antigens (genetics)
• HLA-B Antigens (genetics)
• HLA-DR4 Antigen (genetics)
• Humans
• Russia