Prevention of flare recurrences in childhood-refractory chronic uveitis: an open-label comparative study of adalimumab versus infliximab.

Abstract

OBJECTIVE:

To compare the efficacy and safety of adalimumab versus infliximab in an open-label prospective, comparative, multicenter cohort study of childhood noninfectious chronic uveitis.

METHODS:

Thirty-three patients (22 females, 11 males, median age 9.17 years) with refractory, vision-threatening, noninfectious active uveitis were enrolled, and received for at least 1 year infliximab (5 mg/kg at weeks 0, 2, and 6, and then every 6-8 weeks) or adalimumab (24 mg/m2 every 2 weeks). The primary outcome was to assess, once remission was achieved, the time of a first relapse. Time to remission, time to steroid discontinuation, and the number of relapses were also considered.

RESULTS:

Sixteen children (12 with juvenile idiopathic arthritis [JIA], 3 with idiopathic uveitis, and 1 with Behçet's disease) were recruited in the adalimumab cohort and 17 children (10 with JIA, 5 with idiopathic uveitis, 1 with early-onset sarcoidosis, and 1 with Behçet's disease) were recruited in the infliximab group. Cox regression analysis did not show statistically significant differences between the two groups with regard to time to achieve remission and time to steroid discontinuation, whereas a higher probability of uveitis remission on adalimumab during the time of treatment was shown (Mantel-Cox χ2=6.83, P<0.001). At 40 months of followup, 9 (60%) of 15 children receiving adalimumab compared to 3 (18.8%) of 16 children receiving infliximab were still in remission on therapy (P<0.02).

CONCLUSION:

Even if limited to a relatively small group, our study suggests that over 3 years of treatment, adalimumab is more efficacious than infliximab in maintaining remission of chronic childhood uveitis.

• Authors: Gabriele Simonini, Andrea Taddio, Marco Cattalini, Roberto Caputo, Cinzia De Libero, Samuele Naviglio, Cecilia Bresci, Monica Lorusso, Loredana Lepore, Rolando Cimaz
• Journal: Arthritis care & research (Arthritis Care Res (Hoboken)) Vol. 63 Issue 4 Pg. 612-8 (Apr 2011) ISSN: 2151-4658 [Electronic] United States
• PMID: 21452272 (Publication Type: Comparative Study, Journal Article, Multicenter Study)
• Copyright: Copyright © 2011 by the American College of Rheumatology.

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Infliximab
• Adalimumab

Topics

• Adalimumab
• Adolescent
• Age Factors
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Humanized
• Child
• Child, Preschool
• Chronic Disease
• Cohort Studies
• Female
• Humans
• Infliximab
• Male
• Prospective Studies
• Secondary Prevention
• Treatment Outcome
• Uveitis (drug therapy, pathology, prevention & control)