Case of acquired hemophilia with factor VIII inhibitor in a mother and newborn.

Abstract

We report a mother and newborn in the puerperium with hemorrhage secondary to factor VIII inhibitor. A 31-year-old gravida 1 para 1 delivered at a local clinic with a massive postpartum hemorrhage. The activated partial thromboplastin time was prolonged and factor VIII inhibitor was detected. The persistent hemorrhage improved following treatment, including transfusion, steroid therapy, and bypass therapy with factor VII formulations. After hysteroscopic removal of the retained placenta, the hemorrhage decreased. The newborn developed significant swelling of the hands after routine blood sampling and factor VIII inhibitor was detected. The inhibitor disappeared without any special treatment in the 5th month postpartum in the mother and the 4th month postpartum in the newborn. Factor VIII inhibitor may be transferred via the placenta from the mother to the fetus. Therefore, the newborn should also be carefully observed in a case of massive hemorrhage after delivery.

• Authors: Yasushi Kotani, Mitsuru Shiota, Masahiko Umemoto, Eiji Koike, Mitsuhiro Tsuritani, Hiroshi Hoshiai
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 37 Issue 8 Pg. 1102-5 (Aug 2011) ISSN: 1447-0756 [Electronic] Australia
• PMID: 21450023 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.

Chemical References

• Factor VIII

Topics

• Adult
• Edema (etiology, immunology)
• Factor VIII (antagonists & inhibitors)
• Female
• Hand
• Hemophilia A (immunology, physiopathology)
• Humans
• Infant, Newborn
• Maternal-Fetal Exchange
• Postpartum Hemorrhage (etiology, immunology, therapy)
• Pregnancy
• Remission, Spontaneous