Characteristics of NDM-1-producing Escherichia coli isolates that belong to the successful and virulent clone ST131.

Abstract

An NDM-1 carbapenemase-producing Escherichia coli isolate of sequence type 131 (ST131) that belonged to phylogenetic group B2 was obtained from a patient with a urinary tract infection who returned to the United States after a recent hospitalization while visiting India. NDM-1-producing E. coli ST131 had significantly more virulence factors than NDM-1-producing E. coli ST101, previously isolated from a patient in Canada. The presence of NDM β-lactamases in a very successful and virulent E. coli sequence type is of concern.

• Authors: Gisele Peirano, Paul C Schreckenberger, Johann D D Pitout
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 55 Issue 6 Pg. 2986-8 (Jun 2011) ISSN: 1098-6596 [Electronic] United States
• PMID: 21444703 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• beta-Lactamases
• beta-lactamase NDM-1

Topics

• Adult
• Escherichia coli (classification, enzymology, pathogenicity)
• Humans
• Male
• Phylogeny
• Polymerase Chain Reaction (methods)
• Urinary Tract Infections (microbiology)
• Virulence
• beta-Lactamases (biosynthesis)