Effect of tetragastrin on azaserine-induced carcinogenesis in rat pancreas.

Abstract

The effect of tetragastrin on pancreatic tumors induced by azaserine was investigated in Wistar rats. Rats were given 25 weekly injections of 10 mg/kg body weight of azaserine and 1 mg/kg body weight of tetragastrin as a suspension in olive oil every other day. Carcinogen-induced pancreatic lesions were examined by histochemical techniques, and were classified as ATPase-positive or ATPase-negative. In week 62, quantitative histological analysis showed that prolonged administration of tetragastrin had little or no influence on the number and size of the carcinogen-induced pancreatic lesions, although it caused significantly increased cell proliferation, indicated by a greater labelling index of the pancreatic acinar cells.

• Authors: M Tatsuta, H Iishi, M Baba, A Nakaizumi
• Journal: International journal of cancer (Int J Cancer) Vol. 46 Issue 3 Pg. 489-92 (Sep 15 1990) ISSN: 0020-7136 [Print] United States
• PMID: 2144263 (Publication Type: Journal Article)

Chemical References

• Gastrins
• Tetragastrin
• Azaserine
• Adenosine Triphosphatases

Topics

• Adenosine Triphosphatases (analysis)
• Animals
• Azaserine
• Body Weight (drug effects)
• Cell Division (drug effects)
• Gastrins (pharmacology)
• Male
• Mitotic Index
• Organ Size (drug effects)
• Pancreatic Neoplasms (chemically induced, enzymology, pathology)
• Rats
• Rats, Inbred Strains
• Tetragastrin (pharmacology)