Abstract |
The effect of tetragastrin on pancreatic tumors induced by azaserine was investigated in Wistar rats. Rats were given 25 weekly injections of 10 mg/kg body weight of azaserine and 1 mg/kg body weight of tetragastrin as a suspension in olive oil every other day. Carcinogen-induced pancreatic lesions were examined by histochemical techniques, and were classified as ATPase-positive or ATPase-negative. In week 62, quantitative histological analysis showed that prolonged administration of tetragastrin had little or no influence on the number and size of the carcinogen-induced pancreatic lesions, although it caused significantly increased cell proliferation, indicated by a greater labelling index of the pancreatic acinar cells.
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Authors | M Tatsuta, H Iishi, M Baba, A Nakaizumi |
Journal | International journal of cancer
(Int J Cancer)
Vol. 46
Issue 3
Pg. 489-92
(Sep 15 1990)
ISSN: 0020-7136 [Print] United States |
PMID | 2144263
(Publication Type: Journal Article)
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Chemical References |
- Gastrins
- Tetragastrin
- Azaserine
- Adenosine Triphosphatases
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Topics |
- Adenosine Triphosphatases
(analysis)
- Animals
- Azaserine
- Body Weight
(drug effects)
- Cell Division
(drug effects)
- Gastrins
(pharmacology)
- Male
- Mitotic Index
- Organ Size
(drug effects)
- Pancreatic Neoplasms
(chemically induced, enzymology, pathology)
- Rats
- Rats, Inbred Strains
- Tetragastrin
(pharmacology)
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